منابع مشابه
Insulin in blood and insulin antibodies.
T HIS presentation is concerned with the state of insulin in plasma rather than the physiologic regulation of insulin secretion. Our own studies on the concentrations of immunoassayable insulin in blood in hyperglycemic and hypoglycemic states have recently been summarized elsewhere [ 7-31. Since insulin in blood has never been extracted and recovered in amounts sufficient to permit its chemica...
متن کاملExtreme Insulin Resistance From Insulin Antibodies (Not Insulin Receptor Antibodies) Successfully Treated With Combination Immunosuppressive Therapy.
A relationship between insulin resistance (IR) and insulin antibodies (IAs) was first described in the 1950s and was thought to be due to the use of nonhuman insulins (1). Since the introduction of human insulin, the presence of IAs and consequent IR was felt to be clinically insignificant (2). The presence of high levels of IAs, associated with random hypoglycemia in insulin-naive patients, is...
متن کاملInsulin-binding antibodies in relation to insulin therapy.
Methods for detecting insulin binding or transporting antibodies are described, involving the use of radioactively labelled insulin (insulin (131)I). These antibodies are detected in a high proportion of patients receiving insulin, particularly those requiring large doses. The protein fractions concerned appear to be the beta and gamma globulins. The significance of the phenomenon is discussed.
متن کاملDiabetes and hypoglycemia due to insulin antibodies.
A patient with "autoimmune diabetes" with reactive hypoglycemia due to anti-insulin antibodies is described. The pathophysiology of the impaired carbohydrate tolerance and reactive hypoglycemia is illustrated by measurements of C-peptide, and free and antibody-bound insulin. Detailed analysis of her antibodies did not provide any evidence in favor of exogenous insulin immunization. Nevertheless...
متن کاملSimplified method for detecting anti-insulin antibodies and insulin-anti-insulin immune complexes.
A simplified approach for estimating free and total anti-insulin antibodies and soluble insulin-anti-insulin immune complexes in serum has been developed and evaluated. For determination of free anti-insulin antibodies, a binding ratio for 125I-labeled insulin at fivefold serum dilution is calculated; the binding ratios obtained are reproducible (run-to-run coefficient of variation, 7.3%) and c...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1969
ISSN: 0032-5473
DOI: 10.1136/pgmj.45.519.32